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Dr. Alan Hirsch, Director of Vascular Medicine at the Minneapolis Heart Institute, and Professor of Epidemiology & Community Health University of Minnesota School of Public Health

NHLBI TO INTRODUCE NEW CAMPAIGN ON LITTLE KNOWN FOURTH LEADING CAUSE OF DEATH IN UNITED STATES

~ Understanding the Disease and Its Risk Factors Key to Saving Lives~

February 2007

Three out of four people aren't aware of peripheral arterial disease (PAD), a common and dangerous vascular disease that affects approximately eight million Americans, according to a new study published in Circulation: Journal of the American Heart Association. The disease occurs when arteries in the legs become narrowed or clogged with fatty deposits, reducing blood flow to the legs. This can result in leg muscle pain when walking and disability, amputation and a poor quality of life.

Blocked arteries found in people with PAD can be a warning sign that other arteries, including those in the heart and brain, may also be blocked, increasing the risk of a heart attack or stroke. In a cross-sectional, population-based telephone survey of 2,501 adults over age 50, researchers found that public awareness of PAD (25 percent) is markedly lower than for other cardiovascular diseases such as stroke (74 percent), coronary artery disease (67 percent) and heart failure (67 percent). Yet, the risk for PAD is equal to or greater than the risk for these conditions.

Survey respondents were much more aware of relatively rare diseases that affect far fewer people, including Lou Gehrig's disease (36 percent), multiple sclerosis (42 percent) and cystic fibrosis (29 percent).

Few Americans know that having PAD significantly increases the risk for heart attack, stroke, amputation and death, the survey showed. Only one in four adults who were familiar with PAD associate the disease with an increased risk of heart attack; only 28 percent associate PAD with an increased risk of stroke; and only 14 percent link PAD with either amputation or death.

PAD affects both women and men and can strike adults of any age. The risk of PAD is increased in people over age 50, particularly in smokers and former smokers, and in people with diabetes, high blood pressure, abnormal cholesterol, a personal history of heart disease or stroke, and in African Americans.

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